β-内酰胺类抗生素残留受体分析法的研究进展

doi:10.11843/j.issn.0366-6964.2014.03.003

Abstract

Abstract:

β-lactam antibiotics are widely used in clinical medicine.However，antibiotic residues in edible animal products are not only trigger the development of bacterial resistance，which has some adverse effects on human health，but also affect the quality of milk，resulting in economic losses.Therefore，it is necessary to develop rapid and reliable analytical methods for detection of β-lactam antibiotic residues in food safety control.The receptor-based screening method become the hotspot in the research and application of antibiotic screening methods，because of its capability of multi-residue detection of a class of drugs，and its characteristic of specificity，high sensitivity，and high degree of automation.In this article，the β-lactam receptors and their preparation are briefly introduced.The receptor-based screening methods are further classified based on the labeling and detection techniques，including radio-receptor assay，enzyme-labeling receptor assay，colloidal gold-labeling receptor assay，enzyme colorimetry，and biosensor receptor assay.Furthermore，the research progress and application of each type of receptor-based screening method in the detection of β-lactam antibiotics are reviewed in details.

CLC Number:

CHENG Gu-yue， PENG Juan， WANG Yu-lian， DONG Xiao-bing，PENG Da-peng， HAO Hai-hong， HUANG Ling-li， YUAN Zong-hui. Advances in Receptor-based Screening Methods for the Detection of β-Lactam Antibiotic Residues[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(3): 354-362.

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Advances in Receptor-based Screening Methods for the Detection of β-Lactam Antibiotic Residues

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